Acute and chronic treatment of Chinese hamsters and mice with 5, 25 and 125 mg/kg isoniazid (INH) given by oral intubation did not enhance the chromosomal aberration frequencies in spermatogonia. The structural and numerical aberration rates remained in the range of spontaneous events even after the
Effects of isoniazid (INH) on the oogenesis of mice
✍ Scribed by G. Röhrborn; V. Sezer; I. -D. Adler; A. Schmaltz; I. H. Pawlowitzki; Ch. Nautsch
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 171 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Mutagenic damages in female germ cells of mice have been tested with the dominant lethal assay and the cytogenetic analysis of unfertilized M II-oocytes. Concluding one can say that from the experimental data presented here do not show any mutagenic effect of INH on oogenesis of different strains of mice can be stated.
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Meiotic chromosomes of spermatocytes from INH-treated male mice and Chinese hamsters were analysed for chromosome aberrations in diakinesis-metaphase I and metaphase II. The experiments were performed in two laboratories while a third laboratory participated in the chromosome evaluation. No enhancem