Effects of intravenous immunoglobulins on T-cell mediated, concanavalin A-induced hepatitis in mice
β Scribed by Haim Shirin; Rafael Bruck; Hussein Aeed; Rami Hershkoviz; Ofer Lider; Gabriel Kenet; Yona Avni; Zamir Halpern
- Book ID
- 111250104
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 575 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0106-9543
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π SIMILAR VOLUMES
## Galectin -1, an endogenous lectin with immunomodulatory activities, induces selective, Fas-independent apoptosis of activated T cells. The aim of the present study was to evaluate the effect galectin-1 exerts on concanavalin A (Con A)-induced hepatitis, a T-cell-dependent model of liver injury.
The liver appears to play an important role in immunological tolerance, for example, during allo-transplantation. We investigated tolerance mechanisms in the model of concanavalin A (ConA)-induced immune-mediated liver injury in mice. We found that a single injection of a sublethal ConA dose to C57B