Effects of intrastriatal cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system

✍ Scribed by M. Clara Sañudo-Peña; Michelle Force; Kang Tsou; Adrienne S. Miller; J. Michael Walker

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 83 KB
• Volume: 30
• Category: Article
• ISSN: 0887-4476
• DOI: 10.1002/(sici)1098-2396(199810)30:2<221::aid-syn12>3.0.co;2-4

✦ Synopsis

The effect of unilateral intrastriatal cannabinoid receptor stimulation on rotational behavior in rats was explored. The potent cannabinoid agonist CP 55,940 (5 µg/0.5 µl) induced contralateral turning when microinjected unilaterally into the striatum. The D 2 dopamine agonist quinpirole reversed this contralateral rotation but failed to affect motor behavior on its own. Finally, the D 1 dopamine agonist SKF 82958 inhibited movement when administered into the striatum and this inhibition was reversed by co-administration of the cannabinoid agonist. Surprisingly, microinjections of the cannabinoid agonist into the striatum induced movement through activation of the striatonigral pathway and/or inhibition of the striatopallidal pathway, while the D 1 dopamine agonist produced the opposite effect.