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Effects of intrapallidal cannabinoids on rotational behavior in rats: Interactions with the dopaminergic system

✍ Scribed by M. Clara Sañudo-Peña; J. Michael Walker

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 91 KB
Volume: 28
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199801)28:1<27::aid-syn4>3.0.co;2-e

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of unilateral intrapallidal cannabinoid receptor stimulation on rotational behavior in rats was explored. The potent cannabinoid agonist CP55,940 (5 µg/0.5 µl) induced ipsilateral turning when microinjected unilaterally into the globus pallidus. The D 2 dopamine agonist quinpirole reversed this ipsilateral rotation but failed to affect motor behavior on its own. Finally, the D 1 dopamine agonist SKF 82958 inhibited movement when administered into the globus pallidus, and this effect was not additive with CP55,940.

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