Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation
โ Scribed by Christa M. Stoscheck; Bradley G. Erwin; James R. Florini; Robert A. Richman; Anthony E. Pegg
- Book ID
- 118284248
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 896 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0021-9541
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๐ SIMILAR VOLUMES
## Abstract Four different approaches were used to test a postulated relationship between ornithine decarboxylase (ODC) activity and L6 muscle cell proliferation. In the first approach, the level of ODC activity in myoblasts was compared to that of myotubes. The fusion of proliferating myoblasts to
Methylglyoxal bis(3-aminopropylamidinohydrazone (MGBA) inhibited S-adenosylmethionine decarboxylase (AdoMetDC) activity competitively with S-adenosylmethionine (AdoMet), showing a Ki value of 2.60 x 10(-5) M. It also inhibited ornithine decarboxylase competitively with ornithine, showing a Ki value