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Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation

โœ Scribed by Christa M. Stoscheck; Bradley G. Erwin; James R. Florini; Robert A. Richman; Anthony E. Pegg


Book ID
118284248
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
896 KB
Volume
110
Category
Article
ISSN
0021-9541

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๐Ÿ“œ SIMILAR VOLUMES


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## Abstract Four different approaches were used to test a postulated relationship between ornithine decarboxylase (ODC) activity and L6 muscle cell proliferation. In the first approach, the level of ODC activity in myoblasts was compared to that of myotubes. The fusion of proliferating myoblasts to

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Methylglyoxal bis(3-aminopropylamidinohydrazone (MGBA) inhibited S-adenosylmethionine decarboxylase (AdoMetDC) activity competitively with S-adenosylmethionine (AdoMet), showing a Ki value of 2.60 x 10(-5) M. It also inhibited ornithine decarboxylase competitively with ornithine, showing a Ki value