✦ LIBER ✦
Antitumor effect of methylglyoxalbis(3-aminopropyl-amidinohydrazone), a new inhibitor ofS-adenosylmethionine and ornithine decarboxylases, on human erythroid leukemia K562 cells
✍ Scribed by H. Hibasami; T. Tsukada; S. Maekawa; M. Sakurai; S. Shirakawa; K. Nakashima
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 346 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0344-5704
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✦ Synopsis
Methylglyoxal bis(3-aminopropylamidinohydrazone (MGBA) inhibited S-adenosylmethionine decarboxylase (AdoMetDC) activity competitively with S-adenosylmethionine (AdoMet), showing a Ki value of 2.60 x 10(-5) M. It also inhibited ornithine decarboxylase competitively with ornithine, showing a Ki value of 3.80 x 10(-5) M. MGBA inhibited the growth of human erythroid leukemia K562 cells. Putrescine, spermidine, and spermine concentrations in MGBA-treated cells were depressed to 19%, 36%, and 66% of the values of control cells, respectively.