Effects of inhibitors of DNA synthesis on spontaneous and ultraviolet light-induced sister-chromatid exchanges in Chinese hamster cells
β Scribed by Yutaka Ishii; Michael A Bender
- Book ID
- 118024932
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 871 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0165-1218
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## Abstract The level of sister chromatid exchanges, both spontaneous and induced by UV light or ethylmethanesulphonate (EMS), in Chinese hamster V79/AP4 cell line, is partially reduced upon cocultivation with human cells. Normal and xeroderma pigmentosum (XP) cells are equally effective. On the ba
Culture of cells in high exogenous levels (greater than 10(-4) M) of bromodeoxyuridine (BrdUrd) or thymidine will increase the baseline sister chromatid exchange (SCE) frequency. The effect is thought to be related to the balance of the DNA precursors thymidine and deoxycytidine. Exogenous addition