✦ LIBER ✦

Effects of indomethacin on demineralized bone-induced heterotopic ossification in the rat

✍ Scribed by Paul E. DiCesare; Marcel E. Nimni; Lynnus Peng; Mohamadreza Yazdi; Dr. David T. Cheung

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 657 KB
Volume: 9
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100090611

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Indomethacin inhibits bone formation when treatment is initiated before the implantation of demineralized bone matrix (DBM). For the inhibition of bone induction to occur, indomethacin treatment had to be initiated 6 h or more before implantation of DBM. Initiating the drug treatment at or after the time of DBM implantation had no effects on the amounts of new bone formed. The inhibition by indomethacin is dose related over a range between 0.04 and 4 mg/kg body weight. Recovered day‐1 DBM implants, transplanted into indomethacin pre‐ and posttreated syngeneic rats, formed bone at the same rate as controls did. However, recovered day‐1 DBM implants lyophilized before transplantation showed decreased bone formation but significant dystrophic calcification as judged by a lower alkaline phosphatase activity and an elevated calcium content.

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