Effects of hypoxia and hyperoxia on the human standing potential

✍ Scribed by Michael F. Marmor; William J. Donovan; David M. Gaba

• Publisher: Springer-Verlag
• Year: 1985
• Tongue: English
• Weight: 261 KB
• Volume: 60
• Category: Article
• ISSN: 0012-4486
• DOI: 10.1007/bf00158923

✦ Synopsis

We report that the human standing potential, measured by the EOG, rises slowly when oxygen saturation is lowered to near 80% by breathing a controlled oxygennitrogen mLxture. The standing potential falls abruptly by 20-30% of its amplitude when the oxygen saturation returns to 100%. These changes can be generated reproducibly, with minimal discomfort, under conditions that could be adopted for clinical use. Animal experimental studies by Linsenmeier and Steinberg suggest that this hypoxia-hyperoxia response may be a delayed response to potassium concentration changes in the subretinal space. Since there is no requirement for light and no involvement of the MOiler cells, the hypoxia-hyperoxia response may be more specific for pigment epithelial pathology than the c-wave.