Effects of human and experimental cancer on the conversion of 14c tripalmitin to 14co2
โ Scribed by Giovanni Costa; Kenneth Lyles; Ludwig Ullrich
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 506 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0008-543X
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The effect of hepatic glutathione depletion on 14CO2 evolution from [14C]methyl-labeled aminopyrine was assessed in fed male Sprague-Dawley rats. Within 30 min of i.p. administration of either diethylmaleate or phorone, hepatic glutathione fell approximately 75 to 80% and remained depressed for the
## Abstract A convenient method of preparing 2โoctyl (4โaminoโ3,5โdichloroโ6โfluoroโ2โpyridinyloxyโ2,6โ^14^C)acetate from glutarimideโ2,6โ^14^C is described. The process includes a novel oneโstep conversion of glutarimideโ2,6โ^14^C to pentachloropyridineโ2,6โ^14^C.
N-Nitrosodiethylamine (NDEA) has been identified as a typical environmental carcinogen. Its metabolism was studied in mice under the influence of an electromagnetic field (EMF). After intraperitoneal administration of [14C]-NDEA, 0.2 microCi/100 g body weight resulted in 22.8% of the total radioacti