Effects of Hormones on Tumor Growth and Immunoreactive Insulin-like Growth Factor-1 of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Transplanted in Nude Mice
โ Scribed by Noguchi, Masakuni ;Koyasaki, Naohiro ;Miyazaki, Itsuo ;Yuji, Yuji
- Book ID
- 108579224
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1991
- Tongue
- English
- Weight
- 287 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0910-5050
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The effects of the novel anti-estrogen EM-343 on the growth of 2 hormone-responsive human breast cancer tumors have been examined in athymic nude mice. At the low daily dose of 5 g, EM-343 administered subcutaneously for 6 months completely blocked the stimulatory effect of endogenous estrogens on t
## Abstract The insulinโlike growth factors (IGFs) are potent mitogens for breast cancer cells and their activity is modulated by high affinity binding proteins (IGFBPs). We have recently shown that IGFBPโ1 purified from human amniotic fluid neutralizes IGFโIโdependent growth of MCFโ7 cells. In thi