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Effects of HLA class I derived peptides on NK activity in vitro

✍ Scribed by R. Tarazona; M.D. Galiani; E. Aguado; R. Solana; J. Peña

Book ID
108409168
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
350 KB
Volume
56
Category
Article
ISSN
0165-2478

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A series of dimeric peptides derived from a conserved HLA Class I hexapeptide sequence have been synthesized and tested for their ability to inhibit T cell-mediated lysis and to disrupt membranes. Structureactivity studies of the C-N/N-C dimer show that activity is especially sensitive to substituti