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Structure-activity studies of CTL inhibitory peptides derived from HLA Class I molecules

✍ Scribed by Erich J Schwartz; Jodi Goldberg; Carol Clayberger; Alan M Krensky; John H Griffin

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 281 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00576-8

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✦ Synopsis

A series of dimeric peptides derived from a conserved HLA Class I hexapeptide sequence have been synthesized and tested for their ability to inhibit T cell-mediated lysis and to disrupt membranes. Structureactivity studies of the C-N/N-C dimer show that activity is especially sensitive to substitution of isoleucine residues. The results further define and delimit the basis for activity by HLA-derived peptides.

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