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Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines

✍ Scribed by Yasushi Adachi; Choon–Taek Lee; Keith Coffee; Noboru Yamagata; Joyce E. Ohm; Kyung–Ho Park; Mikhail M. Dikov; Sorena R. Nadaf; Carlos L. Arteaga; David P. Carbone


Book ID
119756760
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
730 KB
Volume
123
Category
Article
ISSN
0016-5085

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## Abstract ## BACKGROUND High concentrations of insulin‐like growth factor (IGF)‐I and IGF‐II have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGF‐I receptor (IGF‐IR). However, definitive studies of IGF‐IR expres