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Effects of Gender, Pregnancy, and Anesthesia on the Pharmacokinetics of Zidovudine in Rats

โœ Scribed by Christine S.-H. Huang; F. Douglas Boudinot; Stuart Feldman


Book ID
110347009
Publisher
Springer US
Year
1995
Tongue
English
Weight
1001 KB
Volume
12
Category
Article
ISSN
0724-8741

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Pharmacokinetics and saturable renal tub
โœ Bela A. Patel; Chung K. Chu; F. Douglas Boudinot ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 671 KB

The purpose of this study was to assess the effects of dose on the pharmacokinetics of zidovudine (3'-azido-3'-deoxythymidine; AZT) in rats. Zidovudine (AZT) was administered intravenously at doses of 10, 50, 100, and 250 mgikg. Plasma and urine AZT concentrations were determined by HPLC. Plasma AZT