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Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes

✍ Scribed by Elisabetta Chieli; Nadia Romiti; Fabrizio Cervelli; Roberto Tongiani

Book ID
116018763
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
766 KB
Volume
57
Category
Article
ISSN
0024-3205

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The effect of interferon (IFN)-beta and IFN-gamma on P-glycoprotein (P-gp)-mediated efflux of rhodamin-123(Rho-123), a typical substrate of P-gp, was studied in rat hepatocytes in primary culture. After treatment with IFN-beta, IFN-gamma, or both for 3 days, steady-state levels of Rho-123, incorpora