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Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo

✍ Scribed by Yuka Sasakawa; Yoshinori Naoe; Takeshi Inoue; Tatsuya Sasakawa; Masahiko Matsuo; Toshitaka Manda; Seitaro Mutoh

Book ID: 117467797
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 257 KB
Volume: 195
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(03)00184-8

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## Abstract The use of surrogate end‐point biomarkers could help in the development of chemopreventive agents. To define potential surrogate end‐point biomarkers, the ability of budesonide to decrease mRNA expression of the insulin‐like growth factor‐2 (__Igf‐II__) and c‐__myc__ genes and to cause