Effects of enoxacin, ofloxacin and norfloxacin on theophylline disposition in humans
โ Scribed by M. Sano; K. Kawakatsu; C. Ohkita; I. Yamamoto; M. Takeyama; H. Yamashina; M. Goto
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 484 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0031-6970
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On the basis of reports that some calcium channel blockers impair the elimination of some drugs, the effect of nifedipine on the disposition of antipyrine and theophylline was assessed in healthy volunteers. Antipyrine half-life of 10.04 f 1.43 h (mean f SD) after a week intake of nifedipine (20 mg
The effect of domperidone (2 mg kg-') on the pharmacokinetics of a single oral dose of theophylline (25 mg kg-') was studied in the rat. Theophylline concentrations were measured serially for 12 h using an HPLC technique. Domperidone did not have any significant effect on any of the four parameters