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Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines

✍ Scribed by Tsujioka, Takayuki; Yokoi, Akira; Uesugi, Mai; Kishimoto, Mitsuyo; Tochigi, Aki; Suemori, Sinichiro; Tohyama, Yumi; Tohyama, Kaoru

Book ID
120821626
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
650 KB
Volume
41
Category
Article
ISSN
0301-472X

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## Abstract The DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastoma‐ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__‐methyl‐__