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Effects of disopyramide on electrophysiological and mechanical properties of the heart

✍ Scribed by Billy K. Yeh; Pei-Kun Sung; Benjamin J. Scherlag

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
536 KB
Volume
62
Category
Article
ISSN
0022-3549

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✦ Synopsis

Studies were performed in whole dog and in isolated superfused canine Purkinje fiber-papillary muscle preparations to investigate mechanisms responsible for the antiarrhythmic effects of disopyramide. Two human left atrial appendages were also studied in oirro. Disopyramide had a potent quinidine-like effect which may explain the antiarrhythmic properties of disopyrarnide. While disopyramide is perhaps at least twice as potent as quinidine in suppressing experimentally induced arrhythmias, disopyramide also has at least proportionally more depressant effect on cardiac mechanical performance in the dog heart.

Keyphrases 0 Disopyramide-ffects on electrophysiological and mechanical properties of the heart. in citro, in uioo

Antiarrhythmic activity, disopyrarnide-effects on electrophysiological and mechanical properties of the heart, ill oirro, in uioo 0 Quinidine-like activity-ffects of disopyramide on itr uitro and in oiuo electrophysiological and mechanical properties of the heart n Cardiac effects, electrophysiological and mechanical4isopyramide

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