Inbred female CaH/St mice exhibit the normal incidence of spontaneous mammary adenocarcinoma of 80-100% if they are maintained on a standard commercial laboratory diet containing 0.15 ppm of selenium with meat and dried skimmed milk as major sources of protein. The tumor incidence drops to 42% if an
Effects of dietary selenium and of lead on the genesis of spontaneous mammary tumors in mice
โ Scribed by G. N. Schrauzer; K. Kuehn; D. Hamm
- Book ID
- 112964050
- Publisher
- Humana Press Inc
- Year
- 1981
- Tongue
- English
- Weight
- 489 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0163-4984
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Strain N S T female mice maintained on a high fat (I 5 %) diet in which stearic acid was the major lipid component developed initial spontaneous mammary adenocarcinomas at an older age than mice fed a low fat (4.5 %)stock diet Mice placed on the SA diet at weaning developed tumors at 15.7 f 0.87 mon
The inhibitory effect of selenium on the genesis of spontaneous mammary tumors in C3H mice is statistically significant even at toxic levels of selenium (5 and 15 ppm of Se in form of selenite added to the supply water), no evidence for stimulation of tumor growth by selenium has been obtained. Arse