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Effects of dietary fat on drug absorption

✍ Scribed by Zhi, Jianguo; Rakhit, Ashok; Patel, Indravadan H.

Publisher: Nature Publishing Group
Year: 1995
Tongue: English
Weight: 592 KB
Volume: 58
Category: Article
ISSN: 0009-9236
DOI: 10.1016/0009-9236(95)90167-1

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✦ Synopsis

The influence of dietary fat on drug absorption, taking into account the. route of drug absorption, the drug's lipophilicity, the dosage form of the drug, and the quantity of dietary fat in a meal, has been studied to a limited extent. Definitive studies examining the impact of varying quantities of dietary fat intake on drug absorption are few,' with only generic "foodeffect" studies being prevalent. The results of these studies indicate some importance of dietary fat content in meals on drug absorption.*-'

It is suggested that the effect of dietary fat depends strongly on the route of drug absorption, either portal or lymphatic. For the lymphatic route, dietary fat enhances absorption of the presumably dissolved drug, whereas for the portal route, dietary fat enhances absorption of "poorly bioavailable" lipophilic drugs by improving dissolution.

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