Effects of diagnostic ultrasound on sister chromatid exchange frequencies of the amniotic fluid cells of the pregnant women
โ Scribed by Ma Changjun; Chen Yuancha; Chen Sufang; Huo Peidan; Luo Anxue; Zhou Yali; Lin Youlin
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 216 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1435-232X
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The precise nature and significance of SCEs are still not understood. It is clear that SCE analysis is a sensitive means of detecting genotoxic agents, and that SCEs are correlated with mutation, in vitro transformation, and cancer. SCEs, as all other short-term assays, are subject to false positive
Spontaneous and mitomycin-C-induced sister chromatid exchange frequencies were studied in the lymphocytes of 25 oral cancer patients. For these patients, the mean spontaneous SCE value was 8.31 (kSD), which was significantly higher than the value of 6.60 ( S D ) obtained for the controls (p < 0.001)