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Effects of deferrioxamine on iron-catalyzed lipid peroxidation

โœ Scribed by Dennis M. Miller; Nathan H. Spear; Steven D. Aust

Book ID
115709238
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
802 KB
Volume
295
Category
Article
ISSN
0003-9861

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In mice subjected to glutathione depletion by pretreatment with phorone (diisopropylidene acetone, 200 mgl kg i.p. in 10 mlkg olive oil) paracetamol (acetaminophen, 300 mgkg p.0. in 10 ml/kg tylose 2 h later) led to a marked hepatotoxicity as evidenced by increased plasma activities of the liver-spe