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Antidotal effects of deferrioxamine in experimental liver injury — role of lipid peroxidation

✍ Scribed by C.-P. Siegers; B. Steffen; M. Younes

Book ID
114075365
Publisher
Elsevier Science
Year
1988
Weight
259 KB
Volume
20
Category
Article
ISSN
0031-6989

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✍ Maged Younes; Christiane Sause; Claus-Peter Siegers; Robert Lemoine 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 513 KB

In mice subjected to glutathione depletion by pretreatment with phorone (diisopropylidene acetone, 200 mgl kg i.p. in 10 mlkg olive oil) paracetamol (acetaminophen, 300 mgkg p.0. in 10 ml/kg tylose 2 h later) led to a marked hepatotoxicity as evidenced by increased plasma activities of the liver-spe