𝔖 Bobbio Scriptorium
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Effects of decarboxylase inhibition on the biosynthesis of brain monoamines

✍ Scribed by B.B. Brodie; R. Kuntzman; C.W. Hirsch; E. Costa


Book ID
118932758
Publisher
Elsevier Science
Year
1962
Tongue
English
Weight
184 KB
Volume
1
Category
Article
ISSN
0024-3205

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The effect of inhibiting endogenous brain thromboxane (TXB2) on pentylenetetrazole-induced seizures was studied using the thromboxane synthetase inhibitors OKY-1581 (20 mgikg) and UK 38,485 (50 mgikg). Both compounds selectively decreased ( > 90%) TXB2 production in brain measured after 2 min of con