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Effects of D-Lysine Substitutions on the Activity and Selectivity of Antimicrobial Peptide CM15

โœ Scribed by Kaminski, Heather M.; Feix, Jimmy B.

Book ID
121226078
Publisher
MDPI AG
Year
2011
Tongue
English
Weight
559 KB
Volume
3
Category
Article
ISSN
2073-4360

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Effect of Leucine and Lysine substitutio
Effect of Leucine and Lysine substitution on the antimicrobial activity and evaluation of the mechanism of the HPA3NT3 analog peptide
โœ Ramamourthy Gopal; Seong-Cheol Park; Kyeoung-Ju Ha; Seung Joo Cho; Si Wouk Kim; ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 302 KB

## Abstract In this study, a HPA3NT3โ€analog (FKKLKKLFKKILKLKโ€NH~2~) peptide was designed. In this analog, two Trp residues (positions 12, 14) were replaced with Leu, and Arg and Asn (positions 3, 13) were replaced with Lys to investigate the role of amino acid substitution and increased cationicity