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Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism

✍ Scribed by Kosuke Doki; Masato Homma; Keisuke Kuga; Kazutaka Aonuma; Yukinao Kohda

Book ID: 108642324
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 625 KB
Volume: 68
Category: Article
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2009.03435.x

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to