## Abstract Acute physical stresses can occur in the procurement and isolation process and potentially can contribute to islet death or malfunction upon transplantation. A contractional flow device, previously used to subject suspended cells to wellβdefined hydrodynamic forces, has been modified an
Effects of cyclosporine A on the process of vascularization of freely transplanted islets of Langerhans
β Scribed by P. Vajkoczy; B. Vollmar; B. Wolf; M. D. Menger
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 35 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0946-2716
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There is controversy about whether Cyclosporin A (CsA) affects antigen-presenting cell function. Within the skin, Langerhans cells (LC) are very potent antigenpresenting cells. We investigated the effect of CsA on alloantigen presentation by human LC using the in vitro mixed skin-cell lymphocyte rea
In the light of recent attempts to treat newly-diagnosed Type 1 (insulin-dependent) diabetic patients with cyclosporin A, and reports suggesting an impaired glucose tolerance following immunosuppression therapy with cyclosporin A, we investigated the long-term effects of cyclosporin A on islet beta-