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Effects of copper metabolism on neurological functions in Wistar and Wilson’s disease model rats

✍ Scribed by Noriko Fujiwara; Hiroyuki Iso; Nobue Kitanaka; Junichi Kitanaka; Hironobu Eguchi; Tomomi Ookawara; Keiichiro Ozawa; Shigero Shimoda; Daisaku Yoshihara; Motohiko Takemura; Keiichiro Suzuki

Book ID
116293597
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
211 KB
Volume
349
Category
Article
ISSN
0006-291X

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The disposition behaviors and de-coppering effect of triethylenetetramine dihydrochloride (trientine), a selective chelating agent for copper and an 'orphan drug' for Wilson's disease, have been evaluated in an animal model, Long-Evans Cinnamon (LEC) rats, and normal rats (Wistar). In LEC rats, urin