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Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors

✍ Scribed by Garry Wong; Mikko Kuoppamäki; Jarmo Hietala; Hartmut Lüddens; Erkka Syvälahti; Esa R. Korpi


Book ID
117098827
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
396 KB
Volume
314
Category
Article
ISSN
0014-2999

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Following up h e finQng that the non-imidazole drug clozapine shows a considerable histamine H3 receptor antagonistic activiryl 1.21 , a scrim of analogues and metabolites (clorapinc-N-oxide. and N-desmcthylclozapine) were tested for thcir affinity towards thc H3 receptor using the radiolabelled H,