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Effects of chronic treatment with haloperidol and methamphetamine on hippocampal kindled seizures in the cat

✍ Scribed by Kenji Emori; Yoshio Minabe; Yasuyuki Tanii; Masayoshi Kurachi

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 690 KB
Volume: 8
Category: Article
ISSN: 0920-1211
DOI: 10.1016/0920-1211(91)90066-o

No coin nor oath required. For personal study only.

✦ Synopsis

We assessed the effects of chronic treatment with haloperidol (0.5-2 mg/kg/day, p.o., 17 days) and methamphetamine (1-2 mg/kg/day, p.o., 17 days; 4 mg/kg/day, p.o. 9 days) on hippocampal kindled seizures using a kindling procedure with low-frequency (about 3 Hz) electrical stimulation in cats. The number of stimulating pulses required to trigger epileptic afterdischarge (pulse-number threshold, PNT) was considered an indicator of seizure threshold. Haloperidol, 0.5 and 1.0 mg/kg, reduced the duration of epileptic afterdischarge (afterdischarge duration, ADD) without affecting PNT, and 2.0 mg/kg strongly reduced PNT and ADD. Methamphetamine, 2.0 mg/kg, reduced PNT and ADD, and 4.0 mg/kg preferentially reduced PNT. The effects of the two drugs on hippocampal kindled seizures were found to be partially opposite to those on amygdala kindled seizures, suggesting the different response of these limbic structures to dopamine receptor manipulation.

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