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Effects of acute and long-term treatment with the serotonin1A agonist gepirone on hippocampal afterdischarges in rats

✍ Scribed by Yuji Wada; Jun Shiraishi; Mitsuhiko Nakamura; Naohisa Hirao; Yoshifumi Koshino

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
991 KB
Volume
23
Category
Article
ISSN
0893-6609

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✦ Synopsis

We assessed the effects of acute and long-term administration of gepirone, a serotonin,,(5HT,,) agonist, on hippocampal afterdischarges (ADS) elicited by electrical stimulation in rats. Acute single injection of gepirone at 10 mg/kg produced a significant reduction in the AD threshold, with a significant increase in the AD duration. These facilitatory effects of gepirone were completely blocked by the pretreatment with a 5-F&, antagonist NAN-190. Following daily administration of gepirone (10 mg/kg/day) for 21 days, rats were challenged with an acute dose of 10 mg/kg of gepirone. These treatment regimens resulted in the lack of the facilitatory effects of acutely injected gepirone, and no significant changes were found in either AD threshold or AD duration. The present results suggest that gepirone facilitates the generation of hippocampal ADS through the activation of 5HT,, receptors. Long-term treatment with gepirone offset its facilitatory effects, possibly as a result of the desensitization of presynaptic 5-HT autoreceptors.

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