Effects of orotic acid on the developmen
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G. Grecksch; T. Ott; H. Matthies
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Article
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1974
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Springer
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English
β 540 KB
A marked tolerance to both analgesic and eataleptie effects of 20 mg/kg morphine hydroehloride was developed in rats during treatment with daily doses increasing from 20 to 120mg/kg s.c. within 11 days. Daily administration of 100 mg/kg sodium orotate i.p. 14 days before and during treatment with mo