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Effects of cholane compounds on the development of morphine tolerance

✍ Scribed by Hack-Seang Kim; Young-Eun Lee; Ki-Wan Oh; Myung-Koo Lee


Book ID
112915262
Publisher
Springer
Year
1990
Tongue
English
Weight
332 KB
Volume
13
Category
Article
ISSN
0253-6269

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A marked tolerance to both analgesic and eataleptie effects of 20 mg/kg morphine hydroehloride was developed in rats during treatment with daily doses increasing from 20 to 120mg/kg s.c. within 11 days. Daily administration of 100 mg/kg sodium orotate i.p. 14 days before and during treatment with mo