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Effect of a calcium chelator on morphine tolerance development

✍ Scribed by William K. Schmidt; E.Leong Way


Book ID
115876079
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
671 KB
Volume
63
Category
Article
ISSN
0014-2999

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A marked tolerance to both analgesic and eataleptie effects of 20 mg/kg morphine hydroehloride was developed in rats during treatment with daily doses increasing from 20 to 120mg/kg s.c. within 11 days. Daily administration of 100 mg/kg sodium orotate i.p. 14 days before and during treatment with mo