Effects of chlordiazepoxide upon habituation of open-field behavior in white rats

✍ Scribed by Shinkuro Iwahara; Etsuko Sakama

• Publisher: Springer
• Year: 1972
• Tongue: English
• Weight: 430 KB
• Volume: 27
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00422809

✦ Synopsis

Open-field behavior including ambulation, rearing, defecation and urination were observed in naive rats during a 10 rain session each day for 6 consecutive days following administration of D (chlordiazepoxide, 30 mg/kg, p.o.) to Group DD and of S (saline) to Group SS. Group DS received the same dose of D for the first 4 days and S for the last 2 days, while the drug sequence was reversed for Group SD.

For the first few rain in Session 1, ambulation was slightly more frequent under D than under S and rearing was almost identical in frequency under both states, but afterwards the frequency of both was considerably lowered by D. Defecation (observed twice a session) and urination (observed only after session) were also depressed in drugged rats. A clear intersession habituation was found in all four activities following both S and D, but the habituation was not apparent during the last 5 rain of the daily session. The rats subjected to drug-state changes on Day 5 showed increases in these parameters over those with no state change, but this state-dependency was only relative and diminished on the next day.