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Effects of Chitin/Chitosan and Their Oligomers/Monomers on Migrations of Macrophages

โœ Scribed by Yoshiharu Okamoto; Aika Inoue; Katsuyuki Miyatake; Kikumi Ogihara; Yoshihiro Shigemasa; Saburo Minami

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
62 KB
Volume
3
Category
Article
ISSN
1616-5187

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โœฆ Synopsis

Abstract

The effects of chitin/chitosan and their oligomers/monomers on the migrations of mouse peritoneal macrophage (PEM) and the rat macrophage cell line (rMp) were evaluated in vitro. In direct migratory assay using the blind well chamber method, the migratory activity of PEM was enhanced significantly by chitin and chitosan oligomers (NACOS and COS, respectively), but reduced by chitin, chitosan, and the chitosan monomer (GlcN). The migratory activity of rMp was increased significantly by chitin, chitosan, and the polymers, NACOS and GlcN.

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