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Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients

โœ Scribed by Robert M. Post; David R. Rubinow; Thomas W. Uhde; James C. Ballenger; C. Raymond Lake; Markku Linnoila; David C. Jimerson; Victor Reus

Book ID
104771444
Publisher
Springer
Year
1985
Tongue
English
Weight
598 KB
Volume
87
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 micrograms/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxy-phenylglycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man.

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