Effect of carbamazepine on mean urinary free cortisol excretion in patients with major affective illness

✍ Scribed by David R. Rubinow; Robert M. Post; Philip W. Gold; Thomas W. Uhde

• Book ID: 104716678
• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 342 KB
• Volume: 88
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00310525

✦ Synopsis

Carbamazepine, a tricyclic anticonvulsant effective in the treatment of major affective disorder, has been observed to induce cortisol non-suppression following dexamethasone administration. The mechanism of this effect has not been clearly established. In this study, the authors report carbamazepine-induced elevations of mean urinary free cortisol in patients with affective illness. The theoretical and practical implications of these findings are discussed.