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Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice

✍ Scribed by Michal M. Masternak; Khalid A. Al-Regaiey; Marc Michael Del Rosario Lim; Vanesa Jimenez-Ortega; Jacob A. Panici; Michael S. Bonkowski; Andrzej Bartke


Book ID
113614664
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
107 KB
Volume
40
Category
Article
ISSN
0531-5565

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## Abstract In __C. elegans,__ insulin‐like hormone signal pathway plays a significant role in longevity. In particular, __daf‐16__ gene product is indispensable factor for this lifespan‐extension. This signal pathway is critical for dauer formation, which is a similar state to hibernation in mamma