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Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague–Dawley rats

✍ Scribed by Megumi Yamagishi; Midori Natsume; Naomi Osakabe; Hideaki Nakamura; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose


Book ID
117467448
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
117 KB
Volume
185
Category
Article
ISSN
0304-3835

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## Abstract The effect of oral administration of diazoxide on rats bearing mammary carcinomas induced by dimethylbenzanthracene (7,12‐DMBA) or methylnitro sourea (MNU) was investigated. Administration of 300 mg/kg diazoxide caused mild reversible diabetes with maximum glucose levels of 305 ± 74 (co