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Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague–Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats

✍ Scribed by Masao Hirose; Tsuyoshi Yamaguchi; Cui Lin; Naoya Kimoto; Mitsuru Futakuchi; Tetsuya Kono; Sansei Nishibe; Tomoyuki Shirai


Book ID
117466515
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
152 KB
Volume
155
Category
Article
ISSN
0304-3835

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## Abstract The effect of oral administration of diazoxide on rats bearing mammary carcinomas induced by dimethylbenzanthracene (7,12‐DMBA) or methylnitro sourea (MNU) was investigated. Administration of 300 mg/kg diazoxide caused mild reversible diabetes with maximum glucose levels of 305 ± 74 (co