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Effects of antidepressant agents on open field behaviour in rats

✍ Scribed by S. K. Kulkarni; P. C. Dandiya

Publisher
Springer
Year
1973
Tongue
English
Weight
397 KB
Volume
33
Category
Article
ISSN
0033-3158

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✦ Synopsis

Influence of acute and chronic administration of two types of antidepressant drugs i.e. trieye]ic compounds and monoamine oxidase inhibiters (MAOIs), on the Open Field behaviom-in rats was examined. Two types of stereotyped behaviour were observed in the open field test namely simple stereotypy (ambulation) and complex stereotypy (rearing). Chronic administration of MAOIs primarily caused an increase in the simple stereotyped behaviour while tricyclic compounds on repeated administration selectively increased complex stereotyped behaviour. The Open Field behaviour of rats due to MAOIs is comparable to hallucinogens while the pattern seen with tricyclie agent differs from MAOIs and other central nervous system stimulant drugs.

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