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Effects of adalimumab therapy on disease activity and interferon-γ-mediated biochemical pathways in patients with rheumatoid arthritis

✍ Scribed by Kurz, Katharina; Herold, Manfred; Winkler, Christiana; Klotz, Werner; Russe, Elisabeth; Fuchs, Dietmar


Book ID
120041108
Publisher
Informa plc
Year
2011
Tongue
English
Weight
147 KB
Volume
44
Category
Article
ISSN
0891-6934

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## Abstract ## Objective Both type I interferons (IFNα and IFNβ) and type II IFN (IFNγ) signal via pSTAT‐1. Immunohistochemistry and the gene expression signatures of rheumatoid arthritis (RA) synovial tissue suggest an activated IFN/STAT‐1 signaling pathway. The aim of this study was to determine