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No effects of adalimumab therapy on the activation of NF-κB in lymphocytes from patients with severe rheumatoid arthritis

✍ Scribed by Marco Semmler; Ulrike Seeck; Beate Neustadt; Martin Schulz; Helmut Dotzlaw; Gunther Neeck; Martin Eggert

Publisher: Springer
Year: 2007
Tongue: English
Weight: 137 KB
Volume: 26
Category: Article
ISSN: 0770-3198
DOI: 10.1007/s10067-007-0540-2

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## Abstract ## Objective To determine the signal transduction pathways in CD14+ synovial cells from patients with rheumatoid arthritis (RA) after CD40 ligation, and to examine their role in amplifying synovial inflammation in affected joints. ## Methods Expression of messenger RNA was analyzed u