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Effects of a new class I antiarrhythmic drug bidisomide on canine ventricular arrhythmia models

โœ Scribed by Wu Zhenjiu; Takeo Awaji; Akira Hirasawa; Shigeru Motomura; Keitaro Hashimoto


Publisher
Springer
Year
1993
Tongue
English
Weight
872 KB
Volume
119
Category
Article
ISSN
0300-8177

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SC-40230, a-[2-[acetyl( 1 -methylethyl) amino]ethyl]-tr-(2-chlorophenyl)-l -piperidinebutanamide, a new class I antiarrhythmic agent, was tested for efficacy against coronary ligation-induced arrhythmias and ouabain toxicity arrhythmias in dogs. Doses of 9 mg/kg i.v. and 15, 25, and 35 mgikg p.0. s