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Antiarrhythmic effect of a new class 1 antiarrhythmic drug, AN-132, on ventricular arrhythmias in beagles

โœ Scribed by Keitaro Hashimoto; Kozo Watanabe; Harumi Mitsuhashi


Publisher
Springer US
Year
1989
Tongue
English
Weight
534 KB
Volume
3
Category
Article
ISSN
0920-3206

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SC-40230, a-[2-[acetyl( 1 -methylethyl) amino]ethyl]-tr-(2-chlorophenyl)-l -piperidinebutanamide, a new class I antiarrhythmic agent, was tested for efficacy against coronary ligation-induced arrhythmias and ouabain toxicity arrhythmias in dogs. Doses of 9 mg/kg i.v. and 15, 25, and 35 mgikg p.0. s