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Effects of a 5-HT3 receptor antagonist, MDL-72222, on morphine and cocaine stimulated elevation of extracellular dopamine

✍ Scribed by Pirjo Lillsunde; Aino Kivinen; Minna Mäkinen; Liisa Ahtee; Timo Seppälä

Book ID
119118502
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
161 KB
Volume
53
Category
Article
ISSN
0167-0115

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Synthesis and regional rat brain distrib
Synthesis and regional rat brain distribution of [11C]MDL 72222: a 5HT3 receptor antagonist
✍ L. Barré; D. Debruyne; M.C. Lasne; F. Gourand; G. Bonvento; R. Camsonne; M. Moul 📂 Article 📅 1992 🏛 Elsevier Science ⚖ 596 KB

MDL 72222, an antagonist of 5HT3 receptors, was labeled with a specific radioactivity of 340-400 mCi/mumol by alkylation of the nor-precursor with [11C]CH3I. The yield of the synthesis, starting from [11C]methyliodide to the purified product and corrected for decay, was good approximately 70-75%. Af