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Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice

✍ Scribed by T. Kos; P. Popik; M. Pietraszek; D. Schäfer; W. Danysz; O. Dravolina; E. Blokhina; T. Galankin; A.Y. Bespalov


Book ID
118436705
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
226 KB
Volume
16
Category
Article
ISSN
0924-977X

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MDL 72222, an antagonist of 5HT3 receptors, was labeled with a specific radioactivity of 340-400 mCi/mumol by alkylation of the nor-precursor with [11C]CH3I. The yield of the synthesis, starting from [11C]methyliodide to the purified product and corrected for decay, was good approximately 70-75%. Af