In order to find, whether 8-MOP has an inhibiting effect on the proliferation of lymphocytes in the dark, we studied in vitro the lymphocyte proliferation by a mitogen (HgCl2) and by an antigen (tuberculin) from 16 psoriatic patients during the first oral PUVA treatment immediately before 8-MOP inta
✦ LIBER ✦
Effects of 8-Methoxypsoralen (8-MOP) and UVA on human lymphocytes
✍ Scribed by G. Lischka; Elisabeth Bohnert; G. Bächtold; E. G. Jung
- Publisher
- Springer-Verlag
- Year
- 1977
- Tongue
- English
- Weight
- 322 KB
- Volume
- 259
- Category
- Article
- ISSN
- 0340-3696
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The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP + long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP + UVA.